missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protéines recombinantes
  4. Gibco™ PeproGMP® Human SCF Recombinant Protein, PeproTech®

Gibco™ PeproGMP® Human SCF Recombinant Protein, PeproTech®

Code produit 30276211
Change view
Click to view available options
Quantité:
1 mg
100 μg
50 μg
Conditionnement:
100µg
1mg
50µg
3 product options available for selection
Product selection table with 3 available options. Use arrow keys to navigate and Enter or Space to select.
Code produit Quantité unitSize
30276211 100 μg 100µg
30275009 1 mg 1mg
30276212 50 μg 50µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 3 options available.
3 options
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.
Code produit 30276211 Fournisseur Gibco™ Code fournisseur GMP30007100UG

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!

Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Description

Recombinant Protein

The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P21583
À utiliser avec (application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formule Protein with no preservative
Identification génétique (Entrez) 4254
Poids moléculaire 18.4 kDa
Nom PeproGMP™ Human SCF
Méthode de purification Purified
Quantité 100 μg
Conditions de stockage -20°C or -80°C if preferred
État réglementaire GMP
Concentration en endotoxines ≤0.1 EU/μg
Alias de gène 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Nom usuel SCF
Symbole de gène(s) KITLG
Activité biologique Determined by the proliferation of TF-1 cells. PeproGMP Recombinant Human SCF has been tested against the WHO standard NIBSC 91/682.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA
Contenu et stockage -20°Cor to +80°C if preferred
Activité Determined by the proliferation of TF-1 cells. PeproGMP Recombinant Human SCF has been tested against the WHO standard NIBSC 91/682. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Système d’expression E. coli
Forme Lyophilized
Gamme de produits PeproGMP
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
Afficher plus Afficher moins
Nom du produit
Sélectionnez un problème

En cliquant sur Soumettre, vous reconnaissez que vous pouvez être contacté par Fisher Scientific au sujet des informations que vous avez fournies dans ce formulaire. Nous ne partagerons pas vos informations à d'autres fins. Toutes les informations de contact fournies seront également conservées conformément à notre politique de confidentialité. Politique de confidentialité.