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Eurofins DiscoverX SHP-1 Protein
Description
SHP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
GenBank NM_002831
Spécification
Spécification
| Formule | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 10% glycerol, 0.1 mM EGTA, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Poids moléculaire | 95 kDa |
| Quantité | 10 μg |
| Espèces | Human |
| Recombinant | Recombinant |
| Marqueur de protéine | N-terminal GST |
| Système d’expression | Recombinant enzyme expressed in E. coli cells |
| Forme protéique | Full-length |
| Pureté ou qualité | ≥54% |
| Protéine | SHP-1, active |
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