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Thermo Scientific™ SMART Digest™ Dual Enzyme Columns for HDX-MS Analysis

Code produit 18078081 Tous les produits Thermo Scientific Produits
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Granulométrie:
˜20 μm
Conditionnement:
1 pièce
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Code produit Granulométrie Conditionnement
18078081 ˜20 μm 1 pièce
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Code produit 18078081 Fournisseur Thermo Scientific™ Code fournisseur 60160110
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Expédition estimée: 05-10-2026
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Description

Thermo Scientific™ SMART Digest™ Dual Enzyme Columns for HDX-MS analysis provide fast, reliable digestion of proteins for HDX-MS analysis, helping to provide the sequence characterization of biotherapeutics.

Thermo Scientific SMART Digest Dual Enzyme columns containing pepsin and protease XIII provide fast, reliable digestion of proteins for for HDX-MS analysis helping to provide the sequence characterization of biotherapeutics.

SMART Digest Dual Enzyme columns for HDX-MS analysis help to provide the characterization of biotherapeutics.

The combination of enzymes are complementary, creating many short, overlapping N-terminal peptides for a high degree of sequence coverage.

Pepsin cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine, tryptophan and tyrosine. It will not cleave at bonds containing valine, alanine or glycine. The optimum pH range for pepsin activity is 1.0–3.0.

Proteinase XIII cleaves proteins preferentially at carboxylic groups of basic amino acids (arginine, lysine, histidine). Like pepsin, Proteinase XIII is active at low pH.

TRUSTED_SUSTAINABILITY

Spécification

Type SMART Digest Pepsin/Protease XIII Dual Enzyme column
Description SMART Digest Pepsin/Protease XIII Dual Enzyme Column
Enzymes Pepsin & Protease XIII
Cleavage Pepsin: Cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine, tryptophan and tyrosine. The optimum pH range for pepsin activity is 1.0–3.0.

Protease XIII: Cleaves proteins preferentially at carboxylic groups of basic amino acids (arginine, lysine, histidine). Like pepsin, Proteinase XIII is active at low pH.
À utiliser avec (application) HDX-MS analysis
Format de colonne Immobilized enzyme
Diamètre 2.1 mm
Débit 10 to 500 μL/min
Pression max. 2500 psi (170 bar)
Longueur 30 mm
Compatibilité de phase mobile Phosphate buffer pH 4
Granulométrie ˜20 μm
pH 2 to 6
Porosité ° 1000 angstroms
Plages de températures de fonctionnement 4 °C to 50 °C
Température de stockage RT for up to 2 weeks; 4 °C for extended period (refrigerate in MES pH 6)
Phase stationnaire Immobilized enzyme
Matériau de remplissage Hydrophilic/coated DVB
Type de colonne Immobilized enzyme in PEEK cartridge
Technique BioLC
Stabilité 1 year
Poids 8 g
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