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Topotecan hydrochloride, R&D Systems™

Product Code. 18772544
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18772544 10 mg 10mg
18742584 50 mg 50mg
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Product Code. 18772544 Supplier Tocris Bioscience Supplier No. 4562/10

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Description

A Tocris product, part of R&D Systems. DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 119413-54-6
Formule moléculaire C23H23N3O5
Poids moléculaire (g/mol) 421.45
Numéro MDL MFCD28989044
Clé InChI UCFGDBYHRUNTLO-QHCPKHFHSA-N
Synonyme topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
CID PubChem 60699
Nom IUPAC (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O

Specifications

Nom chimique ou matériau Topotecan hydrochloride
Quantité 10 mg
Poids de la formule 457.91
Pourcentage de pureté >98%
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