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Aluminon, Thermo Scientific Chemicals

Product Code. 11468366
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Product Code. 11468366

Brand: Thermo Scientific Alfa Aesar A15401.18

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Description

CAS: 569-58-4 | C22H23N3O9 | 473.438 g/mol

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Il s’agit d’un puissant inhibiteur de la ribonucléase et de la topoisomérase II en empêchant la liaison de l’acide nucléique à l’enzyme. Il stimule les processus de phosphorylation de la tyrosine, notamment la voie Jak2/STAT5 dans les cellules du lymphome NB2, l’ErbB4 dans les cellules neuroblastomes et les kinases MAP, les protéines Shc, la phosphatidylinositide 3-kinase et la phospholipase C dans les cellules PC12. L’acide aurintricarboxylique inhibe l’apoptose dans de nombreux types de cellules.

Solubilité
Soluble dans l’eau (800 g/L).

Remarques
Stockez-le dans un endroit frais. Garder le récipient bien fermé dans un endroit sec et bien ventilé. Conserver à l’écart des agents oxydants forts.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 569-58-4
Formule moléculaire C22H23N3O9
Poids moléculaire (g/mol) 473.438
Numéro MDL MFCD00040925
Clé InChI AIPNSHNRCQOTRI-UHFFFAOYSA-N
Synonyme Aurintricarboxylic acid triammonium salt
CID PubChem 54729869
ChEBI CHEBI:87398
Nom IUPAC Triazanium ; 5-[(3-carboxy-4-oxydophényl)-(3-carboxy-4-oxycyclohexa-2,5-dien-1-ylidène)méthyl]-2-oxidobenzoate
SMILES C1=CC(=C(C=C1C(=C2C=CC(=O)C(=C2)C(=O)O)C3=CC(=C(C=C3)[O-])C(=O)[O-])C(=O)O)[O-].[NH4+].[NH4+].[NH4+]

Specifications

Nom chimique ou matériau Aluminon
Point de fusion 220°C to 225°C (decomposition)
Merck Index 14,322
Informations sur la solubilité Soluble in water(800g/L).
Poids de la formule 473.44
Odeur Odorless
pH 5.3
Quantité 50 g

RUO – Research Use Only

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