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Invitrogen™ Human CHEK2 (CHK2), His Tag Recombinant Protein

Code produit. p-7180914
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Quantité:
1 mg
Conditionnement:
1mg
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Code produit. 10003492

Marque: Invitrogen™ PV3983

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion O96017
Concentration See Label
À utiliser avec (application) Kinase Assay
Formule 50mM tris with 50% glycerol, 0.04% Triton X-100, 150mM NaCl, 4mM DTT, 0.5mM EDTA and no preservative; pH 7.5
Identification génétique (Entrez) 11200
Poids moléculaire 66 kDa
Nom Human CHEK2 (CHK2), His Tag
Plage de pH 7.5
Méthode de purification Purified
Quantité 1 mg
Conditions de stockage -80°C, Avoid Freeze/Thaw Cycles
État réglementaire RUO
Alias de gène CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Nom usuel CHK2
Symbole de gène(s) Chek2
Famille des kinases RAD53 Kinase Family
Type de produit Protein
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Marqueur de protéine His-tag
Séquence Full length
Contenu et stockage -80°C, Avoid Freeze/Thaw Cycles
Groupe de kinases Ser/Thr Kinases: CAMK Group
Conditions d’expédition Dry Ice
Système d’expression Baculovirus
Forme protéique Full Length
Forme Liquid
Catégorie de recherche Drug Development
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