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  5. Tocris Bioscience™ Dacomitinib

Tocris Bioscience™ Dacomitinib
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Code produit. 18735966
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Quantité:
10 mg
50 mg
Conditionnement:
10mg
50mg
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Code produit. 18735966

Marque: Tocris Bioscience™ 6231/50

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Description

Potent irreversible pan ErbB inhibitor

Dacomitinib is a potent irreversible pan ErbB inhibitor (IC50 values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively). Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant to Iressa (Cat. No. 3000). Inhibits tumor growth. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Nom chimique ou matériau (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
CAS 1110813-31-4
Plage de pourcentage du dosage >98%
Quantité 50 mg
Formule moléculaire C24H25ClFN5O2
Poids de la formule Observed MW: 469.94
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