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Invitrogen™ EGFR (ErbB1) d747-749 A750P Recombinant Human Protein
This EGFR (ErbB1) d747-749 A750P Recombinant Human Protein (672-end) was expressed in insect cells.
Marque: Invitrogen™ A33512
Informations supplémentaires : Poids : 0.10000kg
Description
- This EGFR (ErbB1) d747-749 A750P recombinant human protein (672–end) was expressed in insect cells
- EGFR receptor tyrosine kinase is a transmembrane glycoprotein
- Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation
- It also leads to cell proliferation, differentiation, motility, and cell survival
- Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms
- Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines
- Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression, and cell proliferation
- EGFR (ErbB1) d747-749 A750P recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
- Validated for use with the LanthaScreen™ Eu Kinase Binding assay
- Available in multiple pack sizes for convenient use
Spécification
| NP_005219.2 | |
| 10 µg | |
| aa 672 - end | |
| GST Tag, His Tag | |
| Dry Ice | |
| Recombinant, Active, Cytoplasmic, Mutant | |
| Kinase Assay |
| 88.8 kDa | |
| EGF Receptors (ErbBs) | |
| Yes | |
| Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol | |
| Insect | |
| Liquid | |
| Human |