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Invitrogen™ Human EGFR (ErbB1) [G719C], GST Tag Recombinant Protein

Human EGFR (ErbB1) [G719C], GST Tag Recombinant Protein

Marque:  Invitrogen™ A33500

Code nomenclature Nacres: NA.28

Informations supplémentaires : Poids : 0.10000kg

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Code produit. 15980403

  • 524.00€ / 10µg
Expédition estimée: 21-08-2024
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Description

Description

  • This EGFR (ErbB1) G719C recombinant human protein (672–end) was expressed in insect cells
  • EGFR receptor tyrosine kinase is a transmembrane glycoprotein
  • Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation
  • It also leads to cell proliferation, differentiation, motility, and cell survival
  • Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms
  • Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines
  • Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation
  • EGFR (ErbB1) G719C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
  • Validated for use with the Z'-LYTE™ assay
  • Available in multiple pack sizes for convenient use
Spécification

Spécification

NP_005219.2
84.1 kDa
EGF Receptors (ErbBs)
Human
GST Tag
Dry Ice
Kinases & Inhibitors
Liquid
Kinase Assay
10 μg
aa 672 - end
Recombinant
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
Baculovirus
Recombinant, Active, Cytoplasmic, Mutant
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