missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ EGFR (ErbB1) G719C Recombinant Human Protein
This EGFR (ErbB1) G719C Recombinant Human Protein (672-end) was expressed in insect cells.
Marque: Invitrogen™ A33500
Informations supplémentaires : Poids : 0.10000kg
Description
- This EGFR (ErbB1) G719C recombinant human protein (672–end) was expressed in insect cells
- EGFR receptor tyrosine kinase is a transmembrane glycoprotein
- Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation
- It also leads to cell proliferation, differentiation, motility, and cell survival
- Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms
- Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines
- Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation
- EGFR (ErbB1) G719C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
- Validated for use with the Z'-LYTE™ assay
- Available in multiple pack sizes for convenient use
Spécification
| NP_005219.2 | |
| 10 µg | |
| aa 672 - end | |
| GST Tag | |
| Dry Ice | |
| Kinases & Inhibitors | |
| Liquid | |
| Human |
| 84.1 kDa | |
| EGF Receptors (ErbBs) | |
| Yes | |
| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol | |
| Baculovirus | |
| Recombinant, Active, Cytoplasmic, Mutant | |
| Kinase Assay |