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  4. Invitrogen™ Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Invitrogen™ Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Code produit. 10022913
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Quantité:
10 μg
Conditionnement:
1 pièce
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.

Spécification

Numéro d’adhésion P19525
Concentration See Label
À utiliser avec (application) Kinase Assay
Formule 50mM tris with 2mM DTT, 0.5mM EDTA, 50% glycerol, 150mM NaCl, 0.02% Triton X-100 and no preservative; pH 7.5
Identification génétique (Entrez) 5610
Poids moléculaire 62.2 kDa
Nom Human EIF2AK2 (PKR), GST Tag
Plage de pH 7.5
Méthode de purification Purified
Quantité 10 μg
Conditions de stockage -80°C, Avoid Freeze/Thaw Cycles
État réglementaire RUO
Alias de gène 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF2a Kinase; eIF-2A protein kinase 2; EIF2AK1; EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; Prkr; protein kinase R; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; serine/threonine-protein kinase TIK; T-cell viral integration site; Tik; Tyrosine-protein kinase EIF2AK2
Nom usuel PKR
Symbole de gène(s) EIF2AK2
Famille des kinases PEK Kinase Family
Longueur des protéines 252-551
Type de produit Protein
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Marqueur de protéine GST-tag
Séquence 252-551
Contenu et stockage -80°C, Avoid Freeze/Thaw Cycles
Entrée du dosage Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Groupe de kinases Ser⁄Thr Kinases: Other
Conditions d’expédition Dry Ice
Compatibilité des systèmes LanthaScreen™ Antibody, LanthaScreen™ Substrate
Entrée cible EIF2AK2
Gène cible eukaryotic translation initiation factor 2-alpha kinase 2
Système d’expression Insect cells
Famille de protéines Kinases & Inhibitors
Forme protéique Recombinant, Catalytic
Forme Liquid
Sous-type de protéine Serine/Threonine Kinases
Catégorie de recherche Signal Transduction
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