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  5. Tocris Bioscience™ EX 527

Tocris Bioscience™ EX 527
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Code produit. 30001429
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Quantité:
1 mg
10 mg
50 mg
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10mg
1mg
50mg
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Code produit. 30001429

Marque: Tocris Bioscience™ 2780/1

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Description

Selective SIRT1 inhibitor

EX 527 is a selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). In an animal model of Huntington's disease, EX 527 rescues neuronal degeneration, extends lifespan, reduces huntingtin inclusions and prevents ventricular enlargement. EX 527 enhances p53 acetylation in response to DNA damaging agents. Orally bioavailable and brain penetrant.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 49843-98-3
Formule moléculaire C13H13ClN2O

Spécification

Nom chimique ou matériau EX 527
Quantité 1 mg
Poids de la formule 248.71
Pureté >98%
Poids moléculaire 248.71
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