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Invitrogen™ Human ICAM-1 (CD54) Fc Chimera Recombinant Protein
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Quantité:
1 mg
100 μg
Conditionnement:
100µg
1mg
Description
It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (800 μL for 1 mg and 80 μL for 100 μg) be added to the vial to prepare a stock solution of 1.25 mg/mL. Concentration is measured by UV.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Spécification
Spécification
| Numéro d’adhésion | P05362 |
| Concentration | 0.25 mg/mL |
| À utiliser avec (application) | Control, Neutralization |
| Format | Lyophilized |
| Formule | PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4 |
| Identification génétique (Entrez) | 3383 |
| Poids moléculaire | 76.2 kDa |
| Nom | Human ICAM-1 (CD54) Fc Chimera |
| Plage de pH | 7.4 |
| Méthode de purification | Purified |
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