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ACROBiosystems Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free
Marque: ACROBiosystems IT7-H52W4-100UG
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Description
Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) and 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistidSpécification
| NP 000876.3 (ITGA4) and NP_000880.1 (ITGB7) | |
| 100 μg | |
| Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7) | |
| Integrin alpha 4 beta 7,ITGA4andITGB7 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 111.4 kDa (ITGA4) and 81.8 kDa (ITGB7) | |
| Human ITGA4&ITGB7; Heterodimer Protein, His Tag&Tag; Free (IT7-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) and P26010-1 (ITGB7)). | |
| -20°C | |
| Integrin alpha 4 beta 7 | |
| Human | |
| 50 mM Tris, 100 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |