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Gibco™ Human LIF Recombinant Protein, PeproTech®
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Quantité:
1 mg
100 μg
25 μg
250 μg
5 μg
50 μg
500 μg
Conditionnement:
100µg
1mg
250µg
25µg
500µg
50µg
5µg
Description
Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
Spécification
Spécification
| Numéro d’adhésion | P15018 |
| À utiliser avec (application) | ELISA, Functional Assay, Western Blot |
| Formule | protein with no preservative |
| Identification génétique (Entrez) | 3976 |
| Poids moléculaire | 19.7 kDa |
| Nom | Human LIF |
| Quantité | 50 μg |
| Source | E. coli |
| État réglementaire | RUO |
| Concentration en endotoxines | <1 EU/ μg |
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