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Gibco™ Human TIGAR-TAT Recombinant Protein, PeproTech®
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Quantité:
1 mg
100 μg
25 μg
250 μg
5 μg
500 μg
Conditionnement:
100µg
1mg
250µg
25µg
500µg
5µg
Description
Recombinant Human TIGAR-TAT expressed in E.coli is a 31.6 kDa protein containing 283 amino acid residues, including the 269 residues of full-length TIGAR fused to a 14-residue C-terminal peptide containing the TAT transduction domain (GGGYGRKKRRQRRR). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other intracellular proteins into primary, as well as transformed, cells.
Spécification
Spécification
| Numéro d’adhésion | Q9NQ88 |
| À utiliser avec (application) | Functional Assay |
| Formule | protein with no preservative |
| Identification génétique (Entrez) | 57103 |
| Poids moléculaire | 31.6 kDa |
| Nom | Human TIGAR-TAT |
| Quantité | 500 μg |
| Source | E. coli |
| État réglementaire | RUO |
| Concentration en endotoxines | <1 EU/ μg |
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