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Gibco™ Human TPO (Thrombopoietin) Recombinant Protein, PeproTech®

Codice prodotto. 17850343
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Quantité:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Dimensione della confezione:
100µg
10µg
1mg
250µg
2µg
500µg
50µg
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Codice prodotto. 17850343

Marca: Gibco™ 300182UG

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

Recombinant Protein

Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
TRUSTED_SUSTAINABILITY

Specifica

Numéro d’adhésion P40225
À utiliser avec (application) ELISA, Functional Assay, Western Blot
Formule protein with no preservative
Identification génétique (Entrez) 7066
Poids moléculaire 18.6 kDa
Nom Human TPO (Thrombopoietin)
Quantité 2 μg
Source E. coli
État réglementaire RUO
Concentration en endotoxines <1 EU/ μg
Alias de gène C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
Nom usuel Thrombopoietin
Symbole de gène(s) THPO
Activité biologique The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg
Conjugué Unconjugated
Recombinant Recombinant
Séquence SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Contenu et stockage -20°C
Système d’expression E. coli
Forme Lyophilized
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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