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Eurofins DiscoverX JAK1 Protein, Active
Description
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
GenBank NM_002227
Spécification
Spécification
| Formule | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 5 mM β-glycerophosphate, 0.5 mM sodium orthovanadate, 50% v/v glycerol, 0.02% Triton™ X-100, 0.5 mM EDTA, 2 mM DTT. Frozen solution. |
| Poids moléculaire | 61 kDa |
| Quantité | 10 μg |
| Espèces | Human |
| Recombinant | Recombinant |
| Marqueur de protéine | N-terminal GST |
| Système d’expression | Recombinant enzyme expressed in Sf21 insect cells |
| Forme protéique | Truncated |
| Pureté ou qualité | ≥57% |
| Protéine | JAK1, active |
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