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Invitrogen™ Human MAP2K4 (MEK4), GST Tag Recombinant Protein

Code produit. 17178745
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Quantité:
1 mg
10 μg
100 μg
Conditionnement:
100µg
10µg
1mg
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Code produit. 17178745

Marque: Invitrogen™ A32894

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This MAP2K4 (MEK4) recombinant human protein (full length) was expressed in insect cells. MAP2K4 (MEK4) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen™ Eu Kinase Binding assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for MAP2K4 (MEK4) is NP003001.1.

MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P45985
Concentration See Label
À utiliser avec (application) Kinase Assay
Formule 50mM tris HCl with 150mM NaCl, 0.1mM PMSF, 25% glycerol, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA and no preservative; pH 7.5
Identification génétique (Entrez) 6416
Poids moléculaire 70.6 kDa
Nom Human MAP2K4 (MEK4), GST Tag
Plage de pH 7.5
Méthode de purification Purified
Quantité 100 μg
Conditions de stockage -80°C, Avoid Freeze/Thaw Cycles
État réglementaire RUO
Alias de gène C-JUN N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; JNKK1; MAP kinase activator 2; MAP kinase kinase 4; Map2k4; map2k4.L; map2k4a; map2k4-a; map2k4-b; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; mitogen activated protein kinase kinase 4; mitogen activated protein kinase kinase 4, variant 1; mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4 L homeolog; mitogen-activated protein kinase kinase 4a; MKK4; mkk4a; MKK4A-l; PRKMK4; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SAPKK1; SAPKK-1; Sek1; Serk1; Skk1; Stress-activated protein kinase kinase 1; XELAEV_18044157mg; XMEK2; zgc:136500; zMKK4 protein
Nom usuel MAP2K4
Symbole de gène(s) MAP2K4
Famille des kinases MAP Kinases
Type de produit Protein
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Marqueur de protéine GST-tag
Séquence Full length
Contenu et stockage -80°C, Avoid Freeze/Thaw Cycles
Conditions d’expédition Dry Ice
Système d’expression Insect cells
Forme protéique Full Length, Recombinant, Active
Forme Liquid
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