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Invitrogen™ Human MET (cMET), His Tag Recombinant Protein
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Quantité:
1 mg
10 μg
Conditionnement:
10µg
1mg
Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic.
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Spécification
Spécification
| Numéro d’adhésion | P08581 |
| Concentration | See Label |
| À utiliser avec (application) | Kinase Assay |
| Formule | 20mM tris with 0.5mM EDTA, 100mM NaCl, 2mM DTT, 50% glycerol, 0.05% Triton X-100 and no preservative; pH 7.5 |
| Identification génétique (Entrez) | 4233 |
| Poids moléculaire | 53.7 kDa |
| Nom | Human MET (cMET), His Tag |
| Plage de pH | 7.5 |
| Méthode de purification | Purified |
| Quantité | 10 μg |
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