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Gibco™ Mouse GDF-5 Recombinant Protein, PeproTech®
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Quantité:
1 mg
10 μg
100 μg
250 μg
50 μg
500 μg
Conditionnement:
100µg
10µg
1mg
250µg
500µg
50µg
Description
Recombinant Murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
Spécification
Spécification
| Numéro d’adhésion | P43027 |
| À utiliser avec (application) | Functional Assay |
| Formule | protein with no preservative |
| Identification génétique (Entrez) | 14563 |
| Poids moléculaire | 27 kDa |
| Nom | Mouse GDF-5 |
| Quantité | 1 mg |
| Source | E. coli |
| État réglementaire | RUO |
| Concentration en endotoxines | <1 EU/ μg |
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