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Pexidartinib, MedChemExpress

Product Code. 16437178
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Product Code. 16437178

Brand: Medchem Express HY16749

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Description

MedChemExpress Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

Specifications

Nom chimique ou matériau Pexidartinib
CAS 1029044-16-3
Couleur Blanc
Notes de qualité de la pureté Research
Formule moléculaire C20H15ClF3N5
Quantité 10 mg
Synonyme PLX-3397
Informations sur la solubilité DMSO : 100 mg/mL (239.34 mM; Need ultrasonic)
SMILES FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
Poids moléculaire (g/mol) 417.81
Poids de la formule 417.81
Pourcentage de pureté 98.0%
Qualité Research
Forme physique Powder
À utiliser avec (application) Cancer-Kinase/protease
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Research purposes only

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