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Invitrogen™ Human SNF1LK2, GST Tag Recombinant Protein
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Quantité:
10 μg
100 μg
Conditionnement:
1 pièce
100µg
Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
Spécification
Spécification
| Numéro d’adhésion | Q9H0K1 |
| Concentration | See Label |
| À utiliser avec (application) | Kinase Assay |
| Formule | 50mM tris with 2mM DTT, 0.04% Triton X-100, 150mM NaCl, 0.5mM EDTA, 50% glycerol and no preservative; pH 7.5 |
| Identification génétique (Entrez) | 23235 |
| Poids moléculaire | 131.4 kDa |
| Nom | Human SNF1LK2, GST Tag |
| Plage de pH | 7.5 |
| Méthode de purification | Purified |
| Quantité | 100 μg |
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