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Invitrogen™ alpha-1 Antitrypsin Monoclonal Antibody (TMF1#4B5)
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Code produit 12817952 Tous les produits Thermo Scientific Produits
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1 mg
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Code produit 12817952 Fournisseur Invitrogen™ Code fournisseur MIA1101

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Description

Mouse Monoclonal Antibody

MIA1101 targets Alpha1-Antitrypsin in IP applications and shows reactivity with Human samples. The MIA1101 immunogen is purified human a1-Antitrypsin. MIA1101 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa. MIA1101 was formerly sold as a Seradyn product.

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
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Spécification

Antigène alpha-1 Antitrypsin
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone TMF1#4B5
Concentration 5 mg/mL
Conjugué Unconjugated
Formule PBS with 0.09% sodium azide; pH 7.4
Expression SERPINA1
Numéro d’ordre du gène P01009
Alias de gène a-1 AT; A1A; a1-antitrypsin; A1AT; AAT; Aat2; Aat-2; alpha 1 antitrypsin; alpha-1 antitrypsin; alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-antitrypsin null; alpha1AT; alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Digestive Zymogen; Dom1; MGC23330; MGC9222; PI; PI1; PRO0684; PRO2209; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1); Protease Serine 1; serine (or cysteine) peptidase inhibitor, clade A, member 1A; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; serine proteinase inhibitor, clade A, member 1; serpin A1; Serpin A1a; serpin family A member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; SERPINA1; Serpina1a; Short peptide from AAT; SPAAT; Spi1; Spi1-1; Spi1-3; TRP1; TRY1
Symboles de gène(s) SERPINA1
Espèces hôtes Mouse
Immunogène Purified human a1-Antitrypsin.
Méthode de purification Protein A
Quantité 1 mg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 5265
Espèces cibles Human
Contenu et stockage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Type de produit Antibody
Forme Liquid
Isotype IgG2a
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