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Invitrogen™ AQR Polyclonal Antibody

Description
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). [UniProt].
Spécification
Spécification
| Antigène | AQR |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Polyclonal |
| Concentration | 1 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 |
| Expression | AQR |
| Numéro d’ordre du gène | O60306, Q8CFQ3 |
| Alias de gène | Aqr; aquarius; aquarius homolog; aquarius intron-binding spliceosomal factor; AW495846; fSAP164; functional spliceosome-associated protein 164; IBP160; intron-binding protein aquarius; intron-binding protein of 160 kDa; Kiaa0560; mKIAA0560; RNA helicase aquarius |
| Symboles de gène(s) | AQR |
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Nom du produit
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