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ACROBiosystems Biotinylated Human TIM-3 / HAVCR2 Protein, Avitag™,His Tag

Biotinylated Protein

Marque:  ACROBiosystems TM3-H82E7-200UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15877797

  • 1392.13€ / 200µg
Date d’expédition estimée: 28-12-2021

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Description

Description

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 23.1 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_116171.3
HEK293
Human
23.1 kDa
200 µg
Ser 22 - Arg 200
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Precision Avi
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>90% as determined by SDS-PAGE
Biotinylated Human TIM-3, Avitag,His Tag (TM3-H82E7) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1).
-20°C
TIM-3
His Tag and Avi Tag
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