Invitrogen™ C8orf48 Polyclonal Antibody

The C8orf48 gene has been identified as a critical biomarker in colorectal cancer (CRC). Research indicates that C8orf48 plays a significant role in inhibiting tumorigenesis by regulating key signaling pathways. This gene is negatively associated with KRAS, BRAF, and MAP2K2 in normal colorectal tissues and negatively correlated with MAP2K2 in CRC tissues. These associations suggest that C8orf48 may function as a tumor suppressor by modulating pathways involved in cell proliferation, migration, and invasion. The gene's expression and methylation profiles have been extensively studied using data from The Cancer Genome Atlas (TCGA), and functional assays have confirmed its inhibitory effects on CRC cell growth. Additionally, C8orf48 has been identified as a direct target of miR-556, further elucidating its regulatory mechanisms. The findings underscore the potential of C8orf48 as a novel target for CRC prediction and therapy.