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PeproTech CCL3 Polyclonal Antibody, PeproTech®, Invitrogen™

Code produit 17813773
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100 μg
50 μg
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100µg
1mg
50µg
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Code produit Quantité unitSize
17813773 50 μg 50µg
17823703 100 μg 100µg
17863173 1 mg 1mg
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Code produit 17813773 Fournisseur PeproTech Code fournisseur 500P7750UG

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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Rat MIP-1alpha (CCL3). Anti-Rat MIP-1alpha (CCL3)-specific antibody was purified by affinity chromatography employing an immobilized Rat MIP-1alpha (CCL3) matrix. Sandwich ELISA: To detect Rat MIP-1alpha (CCL3) by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Rat MIP-1alpha (CCL3) (500-P77Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Rat MIP-1alpha (CCL3). Western Blot: To detect Rat MIP-1alpha by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Rat MIP-1alpha is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
TRUSTED_SUSTAINABILITY

Spécification

Antigène CCL3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugué Unconjugated
Formule PBS with no preservative
Expression Ccl3
Numéro d’ordre du gène P50229
Alias de gène AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1a; MIP-1alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5
Symboles de gène(s) Ccl3
Espèces hôtes Rabbit
Immunogène E.coli-derived Recombinant Rat MIP-1alpha (CCL3).
Méthode de purification Antigen affinity chromatography
Quantité 50 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 25542
Espèces cibles Rat
Contenu et stockage -20°C
Type de produit Antibody
Forme Lyophilized
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