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  6. Invitrogen™ CD284 (TLR4) Monoclonal Antibody (HTA125), Super Bright™ 600, eBioscience™, Invitrogen™

Invitrogen™ CD284 (TLR4) Monoclonal Antibody (HTA125), Super Bright™ 600, eBioscience™, Invitrogen™
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Code produit 16321544
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Quantité:
100 Tests
25 Tests
Conditionnement:
100 pièces
25 tests
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Code produit Quantité unitSize
16321544 100 Tests 100 pièces
16297640 25 Tests 25 tests
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Code produit 16321544 Fournisseur Invitrogen™ Code fournisseur 63991742

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Description

Mouse Monoclonal Antibody

Description: The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (catalog No. 14-9949), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948 or 12-9948 rather than 11-9948. Applications Reported: This ISA-3 antibody has been reported for use in flow cytometric analysis.

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
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Spécification

Antigène CD284 (TLR4)
Applications Flow Cytometry
Classification Monoclonal
Clone HTA125
Concentration 5 μL/Test
Conjugué Super Bright 600
Formule PBS with BSA and 0.09% sodium azide; pH 7.2
Expression TLR4
Numéro d’ordre du gène O00206
Alias de gène ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
Symboles de gène(s) TLR4
Espèces hôtes Mouse
Méthode de purification Affinity chromatography
Quantité 100 Tests
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 7099
Espèces cibles Human
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG2a κ
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