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Invitrogen™ CD39 Polyclonal Antibody

Description
In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) CD39 and less than 1% cross-reactivity with rhCD39L2, rhCD39L3 and recombinant mouse CD39L3. Reconstitute at 0.2 mg/mL in sterile PBS.
CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.
Spécification
Spécification
| Antigène | CD39 |
| Applications | Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.2 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 5% trehalose and No Preservative |
| Expression | ENTPD1 |
| Numéro d’ordre du gène | P55772 |
| Alias de gène | 2610206B08Rik; AA408691; ATPDase; Cd39; CD39 antigen; DKFZp686D194; DKFZp686I093; ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; ENTPD1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase-1; SPG64 |
| Symboles de gène(s) | ENTPD1 |
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Nom du produit
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