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CD52 Monoclonal Antibody (CF1D12), PE-Cyanine7, eBioscience™, Invitrogen™
Description
This CF1D12 monoclonal antibody reacts with human CD52, a cell surface glycoprotein expressed in the immune and reproductive systems. CF1D12 is thought to recognize the carbohydrate region of CD52, not the protein core of the molecule. Tissue-specific mod
Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser Human CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a glycoprotein found in the male reproductive tract and immune cells. It is abundantly expressed on the surface of nearly all human peripheral blood lymphocytes. The CD52 antigen is GPI-anchored membrane receptor that consists of a small 12 amino acid peptide attached to a large N-linked carbohydrate group. CD52 is a potent target for inducing cytolysis of mature lymphocytes. Alemtuzumab, a humanized monoclonal antibody targeting CD52, is used as an immunomodulatory drug for the treatment of chronic lymphocytic leukemia, T cell lymphomas, multiple sclerosis, and other diseases.
Specifications
Specifications
| Antigène | CD52 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | CF1D12 |
| Concentration | 5 μL/Test |
| Conjugué | PE-Cyanine7 |
| Formule | PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2 |
| Expression | CD52 |
| Numéro d’ordre du gène | P31358 |
| Alias de gène | Cambridge pathology 1 antigen; CAMPATH-1 antigen; CDW52; Epididymal secretory protein E5; epididymis secretory sperm binding protein Li 171mP; He5; HEL-S-171mP; Human epididymis-specific protein 5 |
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