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  6. Invitrogen™ CD56 (NCAM) Monoclonal Antibody (CMSSB), PE, eBioscience™, Invitrogen™

Invitrogen™ CD56 (NCAM) Monoclonal Antibody (CMSSB), PE, eBioscience™, Invitrogen™

Code produit 15546796
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Quantité:
100 Tests
25 Tests
Conditionnement:
100 tests
25 tests
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Code produit Quantité unitSize
15546796 25 Tests 25 tests
15311916 100 Tests 100 tests
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Code produit 15546796 Fournisseur Invitrogen™ Code fournisseur 12056741

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Description

Mouse Monoclonal Antibody

Description: This CMSSB monoclonal antibody reacts with human CD56, also known as Neural Cell Adhesion Molecule (NCAM). CD56 is a highly glycosylated transmembrane molecule expressed by neurons and plays a role in the homotypic adhesion of neural cells. In the hematopoietic system, CD56 is expressed on NK cells and a subset of T cells referred to as NKT cells. Staining with CMSSB does not block binding of MEM188 or CB56. Applications Reported: This CMSSB antibody has been reported for use in flow cytometric analysis. Applications Tested: This CMSSB antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
TRUSTED_SUSTAINABILITY

Spécification

Antigène CD56 (NCAM)
Applications Flow Cytometry
Classification Monoclonal
Clone CMSSB
Concentration 5 μL/Test
Conjugué PE
Formule PBS with BSA and 0.09% sodium azide; pH 7.2
Expression Ncam1
Numéro d’ordre du gène P13591
Alias de gène adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Symboles de gène(s) Ncam1
Espèces hôtes Mouse
Méthode de purification Affinity chromatography
Quantité 25 Tests
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 4684
Espèces cibles Human
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG1 κ
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For Research Use Only.

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