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ACROBiosystems Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, Fc Tag

Marque:  ACROBiosystems CD0-C5252-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15876107

  • 262.28€ / 100µg
Date d’expédition estimée: 03-01-2022

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Description

Description

B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Spécification

Spécification

Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by reduced SDS-PAGE
Cynomolgus / Rhesus macaque B7-1, Fc Tag (CD0-C5252) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # G7NXN7). In the region Val 35 - Asn 242, the AA sequence of Cynomolgus and Rhesus macaque B7-1 are homologus.
-20°C
B7-1
Fc Tag
HEK293
Cynomolgus / Rhesus macaque
50.5 kDa
100 µg
Val 35 - Asn 242
CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
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