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  6. Invitrogen™ F4/80 Monoclonal Antibody (BM8), Alexa Fluor™ 561, eBioscience™, Invitrogen™

Invitrogen™ F4/80 Monoclonal Antibody (BM8), Alexa Fluor™ 561, eBioscience™, Invitrogen™

Code produit 17156178
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25 μg
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25µg
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17166178 100 μg 100µg
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Code produit 17156178 Fournisseur Invitrogen™ Code fournisseur 505480180

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Description

Rat Monoclonal Antibody

The BM8 MAb reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
TRUSTED_SUSTAINABILITY

Spécification

Antigène F4/80
Applications Flow Cytometry
Classification Monoclonal
Clone BM8
Concentration 0.2 mg/mL
Conjugué Alexa Fluor 561
Formule PBS with 0.09% sodium azide; pH 7.2
Expression ADGRE1
Numéro d’ordre du gène Q61549
Alias de gène ADGRE1; Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; cell surface glycoprotein F4/80; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly71; lymphocyte antigen 71; TM7LN3
Symboles de gène(s) ADGRE1
Espèces hôtes Rat
Méthode de purification Affinity chromatography
Quantité 25 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 13733
Espèces cibles Mouse
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG2a κ
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