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Fl TRAP220/DRIP2 peptide 100µM

Peptide FL TRAP220/DRIP2 100 µM

Marque:  Invitrogen PV4549

Code nomenclature Nacres: NA.26

Informations supplémentaires : Poids : 0.50000kg

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Code produit. 10046892

  • 184.00€ / 1 pièce
Expédition estimée: 12-01-2024
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LanthaScreen™ fluorescent nuclear receptor coregulator peptides contain known interaction motifs and are labeled with fluorescein. These peptides are matched and validated to complement the LanthaScreen™ TR-FRET Nuclear Receptor Coregulator Assays. Assays developed using these reagents enable primary or secondary screening of nuclear receptor agonists and/or antagonists.

How they work
Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes. TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide. In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein. An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide (Figure 1). The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio (Figure 2).

Contents and Storage:

LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100μM solutions in peptide-appropriate buffers. Store peptides at -20°C.


-5°C to -30°C
Pharma and biopharma, target and lead identification and validation
FL TRAP220/DRIP2 Peptide
RUO - research use only
FL TRAP220/DRIP2 Peptide
FL TRAP220/DRIP2 Peptide 100μm, 100μL, 2554Da Molecular Weight, ≥90% Purity, Fluorescein-NTKNHPMLMNLLKDNPAQD Peptide Sequence, –5 to –30°C Storage, Used For Pharma and Biopharma, Target and Lead Identification and Validation
100 μL
50mM HEPES (pH 7.5)




For Research Use Only. Not for use in diagnostic procedures.