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Description
Immunogen sequence: EEPVIITRNS HPAELDLPRA PQPPNALGYT VSSFSNGCPG EGPRFSAPRR LSTSSLRHPS LGEESTHALI APDEQSHTYV NTPASEDDHR Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 78%.
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
Spécification
Spécification
| Antigène | FRS3 |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Polyclonal |
| Concentration | 0.2 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Expression | FRS3 |
| Numéro d’ordre du gène | O43559 |
| Alias de gène | 4930417B13Rik; AI449674; FGFR substrate 3; FGFR-signaling adaptor SNT2; Fibroblast growth factor receptor substrate 3; FRS2B; Frs2beta; FRS2-beta; FRS3; Snt2; SNT-2; Suc1-associated neurotrophic factor target 2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); testicular tissue protein Li 71 |
| Symboles de gène(s) | FRS3 |
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