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Invitrogen™ GDF5 Polyclonal Antibody
Description
Recommended positive controls: IMR32. Predicted reactivity: Human (99%), Mouse (96%), Pig (98%), Rabbit (98%), Chicken (83%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
Spécification
Spécification
| Antigène | GDF5 |
| Applications | Functional Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.65 mg/mL |
| Conjugué | Unconjugated |
| Formule | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Expression | GDF5 |
| Numéro d’ordre du gène | P43026 |
| Alias de gène | BDA1C; Bmp14; BMP-14; Bone morphogenetic protein 14; bp; brachypodism; brp; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP1; Cdmp-1; GDF5; GDF-5; growth differentiation factor 5; growth/differentiation factor 5; H-GDF-5; LAP4; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; OS5; radotermin; SYM1B; SYNS2 |
| Symboles de gène(s) | GDF5 |
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Nom du produit
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