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PeproTech GM-CSF Polyclonal Antibody, PeproTech®, Invitrogen™

Code produit 17883663
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Quantité:
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100 μg
50 μg
Conditionnement:
100µg
1mg
50µg
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17883663 50 μg 50µg
17883113 100 μg 100µg
17833513 1 mg 1mg
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Code produit 17883663 Fournisseur PeproTech Code fournisseur 500P6550UG

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Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Murine GM-CSF. Anti-Murine GM-CSF-specific antibody was purified by affinity chromatography employing an immobilized Murine GM-CSF matrix. Sandwich ELISA: To detect mGM-CSF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Murine GM-CSF (500-P65Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant mGM-CSF. Western Blot: To detect mGM-CSF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant mGM-CSF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Spécification

Antigène GM-CSF
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugué Unconjugated
Formule PBS with no preservative
Expression CSF2
Numéro d’ordre du gène P01587
Alias de gène colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Symboles de gène(s) CSF2
Espèces hôtes Rabbit
Immunogène E.coli-derived Recombinant Murine GM-CSF.
Méthode de purification Antigen affinity chromatography
Quantité 50 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 12981
Espèces cibles Mouse
Contenu et stockage -20°C
Type de produit Antibody
Forme Lyophilized
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