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Invitrogen™ Human ADAP (aa 19-145) Control Fragment Recombinant Protein
Code nomenclature Nacres: NA.28
    
    
    
    
        
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                                Quantité:
                            
                        
                        
                            
                                100 μl
                            
                        
                    
                            
                                Conditionnement: 
                            
                        
                        
                            
                                100µL
                            
                        
                    Description
Highest antigen sequence indentity to the following orthologs: Mouse (69%), Rat (69%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82934 (PA5-82934. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
                        
                        
                        
                        
                        
                        
                        
                        
                        
                    
                
                
                    
                
                
    
        
            
            Spécification
Spécification
| Numéro d’adhésion | O15117 | 
| Concentration | ≥5.0 mg/mL | 
| À utiliser avec (application) | Blocking Assay, Control | 
| Formule | 1 M urea, PBS with no preservative; pH 7.4 | 
| Identification génétique (Entrez) | 2533 | 
| Nom | Human ADAP (aa 19-145) Control Fragment | 
| Quantité | 100 μl | 
| État réglementaire | RUO | 
| Alias de gène | ADAP; adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; B630013F22Rik; Fyb; Fyb1; FYB-120/130; FYN binding protein; FYN binding protein (FYB-120/130); FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; PRO0823; RGD1563421; Slap130; SLAP-130; SLP-76-associated phosphoprotein | 
| Nom usuel | ADAP | 
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			Invitrogen™ Human ADAP (aa 19-145) Control Fragment Recombinant Protein > 
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