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ACROBiosystems Human Angiopoietin-2 / ANGPT2 (275-496) Protein, His Tag

479.87€ - 2003.42€

Spécification

Numéro d’adhésion AAI26201.1
Poids moléculaire 26.3 kDa
Source Human Angiopoietin-2 (275-496), His Tag (AN2-H5242) is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496 (Accession # AAI26201.1).
Immunogène Lys 275 - Phe 496
Conditions de stockage -20°C
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Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15855907
Afficher les documents Détails de la promotion
ACROBiosystems
AN2-H5242-500UG
500 μg
2003.42€
500µg
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Expédition estimée: 11-04-2024
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15845907
Afficher les documents Détails de la promotion
ACROBiosystems
AN2-H5242-100UG
100 μg
479.87€
100µg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 11-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAI26201.1
Human Angiopoietin-2 (275-496), His Tag (AN2-H5242) is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496 (Accession # AAI26201.1).
-20°C
Angiopoietin-2
Human
20 mM MOPS, 150 mM NaCl, pH7.5
HEK293
Cytokines and Growth Factors
26.3 kDa
Lys 275 - Phe 496
ANGPT2,AGPT2,ANG2,Angiopoietin-2
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by reduced SDS-PAGE
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FDS
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