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ACROBiosystems Human FOLR2 Protein, His Tag

Marque:  ACROBiosystems FO2-H5223-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15856787

  • 287.92€ / 100µg
Expédition estimée: 09-02-2023
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Description

Description

Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.5 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to N-linked glycosylation which has been verified by PNGase F digestion.
Spécification

Spécification

NP_000794.3
26.5 kDa
100 µg
Thr 17 - His 228
FOLR2,BETA-HFR,FBP/PL-1,FR-BETA,FR-P3,FBP
Unconjugated
Tris and Glycine, pH7.5
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human FOLR2, His Tag (FO2-H5223) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - His 228 (Accession # P14207-1).
-20°C
FOLR2
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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