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ACROBiosystems Human HVEM / TNFRSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
sur devis
Spécification
Numéro d’adhésion | NP_003811.2 |
---|---|
Poids moléculaire | 44.4 kDa |
Source | Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (HVM-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # Q92956-1). |
Immunogène | Leu 39 - Val 202 |
Conditions de stockage | -20°C |
Description
Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
NP_003811.2 | |
Human HVEM, Mouse IgG2a Fc Tag, low endotoxin (HVM-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # Q92956-1). | |
-20°C | |
HVEM | |
Human | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
44.4 kDa | |
Leu 39 - Val 202 | |
TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270 | |
Unconjugated | |
Mouse IgG Fc Tag | |
Less than 0.1 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |