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ACROBiosystems Human Neuregulin-4 / NRG4 Protein, His Tag

Marque:  ACROBiosystems NR4-H52H3-50UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15877367

  • 353.08€ / 50µg
Date d’expédition estimée: 03-01-2022

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Description

Description

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 8.6 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

Less than 1.0 EU / µg by the LAL method.
Other Recombinant Proteins
Powder
>90% as determined by SDS-PAGE
Human Neuregulin-4, His Tag (NR4-H52H3) is expressed from human 293 cells (HEK293). It contains AA Pro 2 - Phe 62 (Accession # Q8WWG1).
-20°C
Neuregulin-4
His Tag
HEK293
Human
8.6 kDa
50 µg
Pro 2 - Phe 62
Neuregulin-4,NRG4
Unconjugated
50 mM Tris, 100 mM NaCl, pH7.5
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