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ACROBiosystems Human Serpin A1 Protein, His Tag

Marque:  ACROBiosystems SE1-H5226-50UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15857667

  • 347.90€ / 50µg
Expédition estimée: 08-02-2023
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Description

Description

Serpin A1 is also known as Alpha-1-antitrypsin (A1AT), serum trypsin inhibitor, alpha-1 proteinase inhibitor (A1PI), AAT, which belongs to the serpin family. Most serpins inactivate enzymes by binding to them covalently, requiring very high levels to perform their function. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Serpin A1 / A1AT is inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form of SerpinA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Serpin A1 / A1AT protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.4 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAH11991
45.4 kDa
50 µg
Glu 25 - Lys 418
SerpinA1,PI,A1A,AAT,PI1,A1AT,MGC9222,PRO2275,MGC23330,alpha1AT,SPAAT
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human Serpin A1, His Tag (SE1-H5226) is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Lys 418 (Accession # AAH11991).
-20°C
Serpin A1
His Tag
Less than 1.0 EU / µg by the LAL method.
Other Recombinant Proteins
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