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PeproTech Klotho Polyclonal Antibody, PeproTech®, Invitrogen™

Code produit 17845563
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100 μg
50 μg
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100µg
1mg
50µg
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17845563 50 μg 50µg
17874853 100 μg 100µg
17845413 1 mg 1mg
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Code produit 17845563 Fournisseur PeproTech Code fournisseur 500P29650UG

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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Klotho. Anti-Human Klotho-specific antibody was purified by affinity chromatography employing an immobilized Human Klotho matrix. Sandwich ELISA: To detect Human Klotho by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Klotho (500-P296Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Klotho. Western Blot: To detect hKlotho by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hKlotho is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
TRUSTED_SUSTAINABILITY

Spécification

Antigène Klotho
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugué Unconjugated
Formule PBS with no preservative
Expression KL
Numéro d’ordre du gène Q9UEF7
Alias de gène alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
Symboles de gène(s) KL
Espèces hôtes Rabbit
Immunogène E.coli-derived Recombinant Human Klotho.
Méthode de purification Antigen affinity chromatography
Quantité 50 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 9365
Espèces cibles Human
Contenu et stockage -20°C
Type de produit Antibody
Forme Lyophilized
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