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Invitrogen™ LIF Polyclonal Antibody
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Code produit 15975165
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Quantité:
100 μg
Conditionnement:
100µg
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15975165 100 μg 100µg
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Code produit 15975165 Fournisseur Invitrogen™ Code fournisseur PA579599

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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat brain tissue, rat heart tissue, rat liver tissue, rat kidney tissue, human Hela cell, human placenta tissue, human Jurkat cell, mouse liver tissuemouse kidney tissue.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
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Spécification

Antigène LIF
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugué Unconjugated
Formule PBS with 4mg trehalose and 0.05mg sodium azide
Expression Lif
Numéro d’ordre du gène P09056, P15018, P17777
Alias de gène CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Symboles de gène(s) Lif
Espèces hôtes Rabbit
Immunogène E. coli-derived mouse LIF recombinant protein (Position: S24-F203).
Méthode de purification Antigen affinity chromatography
Quantité 100 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 16878, 3976, 60584
Espèces cibles Human, Mouse, Rat
Contenu et stockage -20°C
Type de produit Antibody
Forme Lyophilized
Isotype IgG
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