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Invitrogen™ MCM7 Polyclonal Antibody

Code produit 13259538
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Quantité:
100 μL
Conditionnement:
100µL
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Code produit Quantité unitSize
13259538 100 μL 100µL
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Code produit 13259538 Fournisseur Invitrogen™ Code fournisseur PA522104

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (92%), Rat (93%), Zebrafish (85%), Xenopus laevis (88%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY

Spécification

Antigène MCM7
Applications ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.76 mg/mL
Conjugué Unconjugated
Formule 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Expression Mcm7
Numéro d’ordre du gène P33993
Alias de gène AI747533; CDC47; CDC47 homolog; CDC47 homolog A; CDC47p; DNA replication licensing factor MCM7; DNA replication licensing factor mcm7-A; DNA replication licensing factor MCM7-like protein; homolog of S. cerevisiae Cdc47; mCDC47; MCM2; MCM7; MCM7 minichromosome maintenance deficient 7; mcm7.S; mcm7-a; mcm7-b; Mcmd7; mini chromosome maintenance deficient 7; minichromosome maintenance complex component 7; minichromosome maintenance complex component 7 S homeolog; minichromosome maintenance deficient 7; minichromosome maintenance deficient 7 (S. cerevisiae); minichromosome maintenance protein 7; minichromosome maintenance protein 7-A; P1 P85MCM; P1.1-MCM3; P1CDC47; P85MCM; p90; PNAS146; PPP1R104; protein phosphatase 1, regulatory subunit 104; Unknown (protein for MGC:128845); XELAEV_18000877mg; XMCM7; xMCM7-A
Symboles de gène(s) Mcm7
Espèces hôtes Rabbit
Immunogène Recombinant protein encompassing a sequence within the center region of human MCM7. The exact sequence is proprietary.
Méthode de purification Antigen affinity chromatography
Quantité 100 μL
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 4176
Espèces cibles Human
Contenu et stockage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Type de produit Antibody
Forme Liquid
Isotype IgG
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