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ACROBiosystems Mouse GITR Ligand / TNFSF18 Protein, Fc Tag

Marque:  ACROBiosystems GIL-M526X-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15876837

  • 431.88€ / 100µg
Expédition estimée: 17-02-2023
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Description

Description

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.4 kDa. As a result of glycosylation, the protein migrates as 45 kDa under reducing (R) condition, and 80-100 kDa under non-reducing (NR) condition (SDS-PAGE)
Spécification

Spécification

AAO89011
41.4 kDa
100 µg
Thr 47 - Ser 173
TNFSF18,AITRL,TL6,hGITRL,GITR Ligand
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Mouse
Powder
>95% as determined by SDS-PAGE
Mouse GITR Ligand, Fc Tag (GIL-M526x) is expressed from human 293 cells (HEK293). It contains AA Thr 47 - Ser 173 (Accession # AAO89011).
-20°C
GITR Ligand
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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