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Invitrogen™ MSL2 Polyclonal Antibody

Description
Immunogen sequence: DKAVKEKIPSH HFMPGSPTKT VYKKPQEKKG CKCGRATQNP SVLTCRGQRC PCYSNRKACL DCICRGCQNS YMANGEKKLE AFAVPEKALE QTRLTLGINV TSIAVRNAST STSVINVTGS PVTTFLAAST HDDKSLDEAI Highest antigen sequence identity to the following orthologs - mouse 99%, rat 100%.
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt].
Spécification
Spécification
| Antigène | MSL2 |
| Applications | Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.1 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Expression | MSL2 |
| Numéro d’ordre du gène | Q9HCI7 |
| Alias de gène | E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; Kiaa1585; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL2; MSL-2; Msl2l1; MSL2-like 1; RGD1310355; ring finger protein 184; Rnf184 |
| Symboles de gène(s) | MSL2 |
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Nom du produit
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