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Invitrogen™ Phospho-PKA beta (Thr198) Polyclonal Antibody
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Description
Antibody detects endogenous levels of PKA beta only when phosphorylated at Thr198, which site historically referenced as Thr197.
The catalytic subunit C-beta of PKA (PRKACB) is a member of the Ser/Thr protein kinase family (the PKA catalytic subunit consist of three gene products: C-alpha, C-beta, and C-gamma) and has been assigned to human chromosome region 1p36.1. PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level C-alpha and C-beta showed 93% homology. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.
Spécification
Spécification
| Antigène | Phospho-PKA beta (Thr198) |
| Applications | Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 1 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 50% glycerol and 0.02% sodium azide |
| Expression | PRKACB |
| Numéro d’ordre du gène | P22694, P68181, P68182 |
| Alias de gène | cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; Pkacb; PRKACB; protein kinase A catalytic subunit beta; protein kinase cAMP-activated catalytic subunit beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, beta |
| Symboles de gène(s) | PRKACB |
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Nom du produit
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