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Phospho-S1P1 (Thr236) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marque: Invitrogen PA538813
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Description
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
Spécification
| Phospho-S1P1 (Thr236) | |
| Polyclonal | |
| Unconjugated | |
| S1PR1 | |
| S1PR1, CD363, CD363 antigen, CHEDG1, ECGF1, EDG-1, D1S3362, EDG1, S1P1, S1P receptor Edg-1, S1P receptor 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 13609, 1901, 29733 | |
| -20°C | |
| Liquid |
| Peptide ELISA, Immunofluorescence | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P21453, O08530, P48303 | |
| S1PR1 | |
| A synthetic phosphopeptide derived from human S1P Receptor EDG1 around the phosphorylation site of Thr236 (R-L-TP-F-R) | |
| 100 μg | |
| Primary | |
| Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG |
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